Pub. Date : 1999 Dec
PMID : 10683762
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells. | Tetradecanoylphorbol Acetate | cyclin D1 | Homo sapiens |
| 2 | The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment. | Tetradecanoylphorbol Acetate | cyclin D1 | Homo sapiens |
| 3 | Thus, it is demonstrated here that the PMA-mediated changes of cyclin D1 and B1 are the result of a persistent increase in extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activity. | Tetradecanoylphorbol Acetate | cyclin D1 | Homo sapiens |