Title : The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations.

Pub. Date : 2000 Feb 29

PMID : 10681455






1 Functional Relationships(s)
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1 Among the thrombin concentrations tested, 50 pM induced intracellular Ca(2+) spikes in fura-2-loaded CA1 neurons whereas higher concentrations caused a sustained Ca(2+) elevation. Fura-2 coagulation factor II Rattus norvegicus