Title : Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis.

Pub. Date : 2000 Mar

PMID : 10681368






1 Functional Relationships(s)
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1 In this study we demonstrated that 7-hydroxyfluperlapine, the major metabolite of fluperlapine in humans, is oxidized to a reactive intermediate by HOCl and by myeloperoxidase in the presence of H(2)O(2) and Cl(-). Water myeloperoxidase Homo sapiens