Title : CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

Pub. Date : 2000 Jan

PMID : 10668853






2 Functional Relationships(s)
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1 Baculovirus-directed cDNA expression revealed that the CYP3A4*2 P450 had a lower intrinsic clearance for the CYP3A4 substrate nifedipine compared with the wild-type enzyme but was not significantly different from the wild-type enzyme for testosterone 6beta-hydroxylation. testosterone 6beta cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Baculovirus-directed cDNA expression revealed that the CYP3A4*2 P450 had a lower intrinsic clearance for the CYP3A4 substrate nifedipine compared with the wild-type enzyme but was not significantly different from the wild-type enzyme for testosterone 6beta-hydroxylation. testosterone 6beta cytochrome P450 family 3 subfamily A member 4 Homo sapiens