Title : The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.

Pub. Date : 2000 Feb 15

PMID : 10666319






2 Functional Relationships(s)
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1 Propranolol (100 nM-10 microM), which inhibits PA phosphohydrolase, blocked the growth stimulated by Ang II, PLD, or PA by as much as 95%, an effect not shared by other beta-adrenergic antagonists. Propranolol angiotensinogen Rattus norvegicus
2 Propranolol also increased the production of PA in the presence of Ang II by 320% and reduced DAG and arachidonic acid (AA) accumulation. Propranolol angiotensinogen Rattus norvegicus