Title : Superoxide anion curbs nitric oxide modulation of afferent arteriolar ANG II responsiveness in diabetes mellitus.

Pub. Date : 2000 Feb

PMID : 10662734






4 Functional Relationships(s)
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1 In kidneys from Sham rats, afferent and efferent arteriolar responses to ANG II (0.1-10.0 nM) were exaggerated significantly by L-NNA. Nitroarginine angiotensinogen Rattus norvegicus
2 L-NNA also augmented efferent arteriolar ANG II responses in kidneys from STZ rats (high-glucose bath) but did not alter ANG II responses in afferent arterioles from STZ rats. Nitroarginine angiotensinogen Rattus norvegicus
3 L-NNA also accentuated efferent, but not afferent, arteriolar ANG II responses in STZ kidneys during acute restoration of bath glucose to normal levels. Nitroarginine angiotensinogen Rattus norvegicus
4 Superoxide dismutase (150 U/ml) restored the ability of L-NNA to allow exaggerated afferent arteriolar responses to ANG II in kidneys from STZ rats. Nitroarginine angiotensinogen Rattus norvegicus