Title : Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.

Pub. Date : 2000 Feb 8

PMID : 10653663






1 Functional Relationships(s)
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1 While AChE adducts with phosphonates and phosphates are known to age through scission of the alkoxy C-O bond, the aging path for adducts with phosphoroamidates (P-N agents) like the nerve agent N,N-dimethylphosphonocyanoamidate (tabun) is not clear. Organophosphonates acetylcholinesterase (Cartwright blood group) Homo sapiens