Title : An immunoreceptor tyrosine-based inhibitory motif, with serine at site Y-2, binds SH2-domain-containing phosphatases.

Pub. Date : 2000 Feb

PMID : 10651806






2 Functional Relationships(s)
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1 Both tyrosyl phosphorylated and thiophosphorylated mast cell function-associated antigen peptides bound the src homology domain 2 (SH2)-containing tyrosine phosphatases-1 (SHP-1), -2 (SHP-2) and inositol 5"-phosphatase (SHIP), though with different efficiencies. cyclo(tyrosyl-tyrosyl) inositol polyphosphate-5-phosphatase D Homo sapiens
2 These results were corroborated by surface plasmon resonance measurements of the interaction between tyrosyl phosphorylated mast cell function-associated antigen peptide and recombinant soluble SH2 domains of SHP-1, SHP-2 and SHIP, suggesting that the associations observed in the cell lysates may be direct. cyclo(tyrosyl-tyrosyl) inositol polyphosphate-5-phosphatase D Homo sapiens