Pub. Date : 2000 Jan
PMID : 10651141
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Preincubation of rat striatal synaptosomes with a specific polyclonal 5-HT1B receptor antibody also resulted in a significant attenuation of the inhibitory effect of CP93,129 on K+-evoked overflow of [3H]DA. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 2 | In conclusion, the results show that a non-competitive antagonist of the 5-HT1B receptor concentration-dependently decreases the maximal inhibitory effect of a 5-HT1B receptor agonist on the synaptosomal K+-evoked release of [3H]DA in striatum. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 3 | In conclusion, the results show that a non-competitive antagonist of the 5-HT1B receptor concentration-dependently decreases the maximal inhibitory effect of a 5-HT1B receptor agonist on the synaptosomal K+-evoked release of [3H]DA in striatum. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 4 | Moreover, a specific antibody raised against the receptor and particularly directed against a region of the receptor protein involved in signal transduction, namely the coupling with the G-protein, also antagonizes the inhibitory effect of the stimulation of 5-HT1B receptor on the release of [3H]DA. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 5 | Ultimately the disruption of 5-HT1B receptor gene in 5-HT1B knock-out mice leads to a total suppression of the effect of 5-HT1B receptor agonists on [3H]DA release. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 6 | Ultimately the disruption of 5-HT1B receptor gene in 5-HT1B knock-out mice leads to a total suppression of the effect of 5-HT1B receptor agonists on [3H]DA release. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 7 | Ultimately the disruption of 5-HT1B receptor gene in 5-HT1B knock-out mice leads to a total suppression of the effect of 5-HT1B receptor agonists on [3H]DA release. | Tritium | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |