Title : Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds.

Pub. Date : 1999 Dec

PMID : 10647906






1 Functional Relationships(s)
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1 Methylenedioxyphenyl compounds which possess a bulky structure such as 1,4-benzothiazine showed substantial inhibition of S-warfarin 7-hydroxylation catalysed by CYP2C9, S-mephenytoin 4"-hydroxylation by CYP2C19, bufuralol 1"-hydroxylation by CYP2D6, and testosterone 6beta-hydroxylation by CYP3A4. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens