Pub. Date : 2000 Jan 1
PMID : 10646848
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we have demonstrated that nickel exposure induced hypoxic signaling pathways by inducing hypoxia-inducible transcription factor-1 (HIF-1), which mediated the induction of genes required by cells to survive hypoxia. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Here we have demonstrated that nickel exposure induced hypoxic signaling pathways by inducing hypoxia-inducible transcription factor-1 (HIF-1), which mediated the induction of genes required by cells to survive hypoxia. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 6 | We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |