Title : Role of cell contractions in cAMP-induced cardiomyocyte atrial natriuretic peptide release.

Pub. Date : 2000 Jan

PMID : 10644591






3 Functional Relationships(s)
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1 Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Colforsin natriuretic peptide A Rattus norvegicus
2 Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Colforsin natriuretic peptide A Rattus norvegicus
3 By contrast, a higher regimen of forskolin (10 microM) promoted a 20- to 30-fold increase in basal cAMP production, which was accompanied by the abolition of contractile activity and ANP release. Colforsin natriuretic peptide A Rattus norvegicus