Pub. Date : 2000 Jan
PMID : 10634525
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of P-glycoprotein function inhibition with cyclosporine A on the biodistribution of Tc-99m sestamibi. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Tc-99m sestamibi is a substrate for P-glycoprotein. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSIONS: With a limited number of patients, this study suggests that Tc-99m sestamibi excretion from the liver is mediated by P-glycoprotein, and inhibition of P-glycoprotein transport not only delays liver excretion but also increases the liver uptake of Tc-99m sestamibi. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSIONS: With a limited number of patients, this study suggests that Tc-99m sestamibi excretion from the liver is mediated by P-glycoprotein, and inhibition of P-glycoprotein transport not only delays liver excretion but also increases the liver uptake of Tc-99m sestamibi. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSIONS: With a limited number of patients, this study suggests that Tc-99m sestamibi excretion from the liver is mediated by P-glycoprotein, and inhibition of P-glycoprotein transport not only delays liver excretion but also increases the liver uptake of Tc-99m sestamibi. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Because this observation deserves further investigation, the inhibition of P-glycoprotein function with nontoxic multidrug-resistance reversing agents may be used as an intervention to increase the tumor uptake of Tc-99m sestamibi and to increase the sensitivity of Tc-99m sestamibi tumor imaging. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Because this observation deserves further investigation, the inhibition of P-glycoprotein function with nontoxic multidrug-resistance reversing agents may be used as an intervention to increase the tumor uptake of Tc-99m sestamibi and to increase the sensitivity of Tc-99m sestamibi tumor imaging. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |