Title : The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6.

Pub. Date : 1999 Dec

PMID : 10634129






2 Functional Relationships(s)
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1 To inhibit cholinesterases, O-demethylgalanthamine was 10-fold more selective for acetylcholinesterase (AChE) versus butyrylcholinesterase (BuChE) than galanthamine. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 To inhibit cholinesterases, O-demethylgalanthamine was 10-fold more selective for acetylcholinesterase (AChE) versus butyrylcholinesterase (BuChE) than galanthamine. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens