Pub. Date : 2000 Jan
PMID : 10631627
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. | Atorvastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Since atorvastatin is a CYP3A4 substrate and many CYP3A4 substrates are also substrates for P-glycoprotein transport, the influence of atorvastatin and its metabolites on P-glycoprotein-mediated digoxin transport in monolayers of the human colon carcinoma (Caco-2) cell line was investigated. | Atorvastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Atorvastatin (100 microM) inhibited digoxin secretion (transport from the basolateral to apical aspect of the monolayer) by 58%, equivalent to the extent of inhibition observed with verapamil, a known inhibitor of P-glycoprotein transport. | Atorvastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |