Title : Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites.

Pub. Date : 1999 Nov 26

PMID : 10630892






2 Functional Relationships(s)
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1 Metabolism of steroid hormones with anabolic properties was studied in vitro using human recombinant CYP3A4, CYP2C9 and 2B6 enzymes. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CYP3A4 enzyme formats incubated with anabolic steroids, testosterone, 17alpha-methyltestosterone, metandienone, boldenone and 4-chloro-1,2-dehydro-17alpha-methyltestosterone, produced 6beta-hydroxyl metabolites identified as trimethylsilyl (TMS)-ethers by a gas chromatography-mass spectrometry (GC-MS) method. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens