Title : Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers.

Pub. Date : 2000 Jan 14

PMID : 10625598






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The SUR2 segment containing the 12th through 17th predicted transmembrane domains, TMD12-17, confers sensitivity to the benzopyran, cromakalim, and the pyridine, pinacidil, whereas an SUR1 segment which includes TMD6-11 and the first nucleotide-binding fold, NBF1, controls responsiveness to the benzothiadiazine, diazoxide. Diazoxide ATP binding cassette subfamily C member 9 Homo sapiens