Pub. Date : 2000 Jan 1
PMID : 10620343
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These findings (i) identify farnesyl diphosphate synthase as the selective target of alendronate in the mevalonate pathway, (ii) show that this enzyme is inhibited by other N-containing bisphosphonates, such as risendronate, but not by clodronate, supporting a different mechanism of action for different bisphosphonates, and (iii) document in purified osteoclasts alendronate inhibition of prenylation and sterol biosynthesis. | Sterols | farnesyl diphosphate synthase | Homo sapiens |