Title : Mitochondrial calcium accumulation following activation of vanilloid (VR1) receptors by capsaicin in dorsal root ganglion neurons.

Pub. Date : 2000

PMID : 10619474






3 Functional Relationships(s)
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1 Mitochondrial calcium accumulation following activation of vanilloid (VR1) receptors by capsaicin in dorsal root ganglion neurons. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 Stimulation of the vanilloid (capsaicin) receptor (VR1), currently viewed as a molecular integrator of chemical and physical noxious stimuli, evoked intracellular Ca2+ transients in a capsaicin-sensitive subpopulation of rat dorsal root ganglion neurons. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
3 The long duration of intracellular Ca2+ decline in neurons stimulated with capsaicin, which depends on the amount of Ca2+ buffered by mitochondria, may reflect a specific mechanism of Ca2+ buffering following activation the pain receptor VR1. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus