Title : Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc.

Pub. Date : 1999 Dec 16

PMID : 10618723






1 Functional Relationships(s)
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1 Whereas cyclin E overexpression alone did not lead to an increased CDK2 activity we observed in all tumors that emerged from either MNU treated normal mice or treated CD2-cyclin E transgenics a downregulation of p27KIP1 and a higher histone H1 kinase activity in CDK2 immunoprecipitates compared to normal tissue. Methylnitrosourea cyclin-dependent kinase inhibitor 1B Mus musculus