Title : The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.

Pub. Date : 2000 Jan 7

PMID : 10617633






1 Functional Relationships(s)
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1 Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells. Cysteine Cbl proto-oncogene Homo sapiens