Title : Regulation of the processing and release of tumor necrosis factor alpha in a human macrophage cell line.

Pub. Date : 1999 Dec

PMID : 10614779






2 Functional Relationships(s)
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1 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha, the PMA-induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroisocoumarin (3,4-DCI), iodoacetamide, and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK). 1,10-phenanthroline tumor necrosis factor Homo sapiens
2 Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-alpha on the cell surface, whereas 3,4-DCI, iodoacetamide, and TPCK inhibited the transport of TNF-alpha to the cell surface. 1,10-phenanthroline tumor necrosis factor Homo sapiens