Title : Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.

Pub. Date : 1999 Dec 21

PMID : 10611319






4 Functional Relationships(s)
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1 Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Tryptophan inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens
2 In agreement with this hypothesis, cells expressing TRPs display novel Ca(2+)-permeable cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein. Tryptophan inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens
3 Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7. Tryptophan inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens
4 Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7. Tryptophan inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens