Title : Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.

Pub. Date : 1999 Dec 18-25

PMID : 10609819






2 Functional Relationships(s)
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1 We analysed the relation between serum concentrations of selected organochlorine compounds and mutations in codon 12 of the K-ras gene in patients with exocrine pancreatic cancer. Hydrocarbons, Chlorinated KRAS proto-oncogene, GTPase Homo sapiens
2 INTERPRETATION: Organochlorine compounds such as p,p"-DDT, p,p"-DDE, and some PCBs could play a part in the pathogenesis of exocrine pancreatic cancer through modulation of K-ras activation. Hydrocarbons, Chlorinated KRAS proto-oncogene, GTPase Homo sapiens