Pub. Date : 2000 Jan
PMID : 10607727
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | We now show, in LIM 1215 colorectal cancer cells, that butyrate, in addition to activating DEVD-caspase and inducing apoptosis, also increases expression and cleavage of the universal cyclin-dependent kinase inhibitor p21(Waf1/Cip1) and leads to hypo-phosphorylation of retinoblastoma protein. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | We now show, in LIM 1215 colorectal cancer cells, that butyrate, in addition to activating DEVD-caspase and inducing apoptosis, also increases expression and cleavage of the universal cyclin-dependent kinase inhibitor p21(Waf1/Cip1) and leads to hypo-phosphorylation of retinoblastoma protein. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | We now show, in LIM 1215 colorectal cancer cells, that butyrate, in addition to activating DEVD-caspase and inducing apoptosis, also increases expression and cleavage of the universal cyclin-dependent kinase inhibitor p21(Waf1/Cip1) and leads to hypo-phosphorylation of retinoblastoma protein. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 7 | Expression of p21 had similar kinetics to that of the essential protein required for DEVD-caspase activation, indicating parallel effects of butyrate on anti-apoptotic and pro-apoptotic mechanisms. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 8 | On the other hand, subsequent culture of these cells for 2-3 days in the absence of butyrate resulted in down-regulation of p21 and restoration of sensitivity to apoptosis by butyrate. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 9 | Here we show, for the first time, that p21 is a target of effector caspases in colorectal cancer cells and that the resistance to butyrate-induced apoptosis is characterized by failure of p21 cleavage. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 10 | Here we show, for the first time, that p21 is a target of effector caspases in colorectal cancer cells and that the resistance to butyrate-induced apoptosis is characterized by failure of p21 cleavage. | Butyrates | cyclin dependent kinase inhibitor 1A | Homo sapiens |