Pub. Date : 1999 Dec 16
PMID : 10602713
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | New prodrugs of daunorubicin and doxorubicin designed for selective activation by the serine protease plasmin are described. | Doxorubicin | plasminogen | Homo sapiens |
2 | A marked in vitro selectivity was demonstrated by incubation of the doxorubicin prodrugs with a plasmin generating MCF-7 breast cancer cell line transfected with urokinase-type plasminogen activator (u-PA) in comparison with the nontransfected nonplasmin generating cell line. | Doxorubicin | plasminogen | Homo sapiens |
3 | Prodrugs 4 and 5 showed the same cytotoxic effect as the free parent drug doxorubicin in the u-PA transfected cells, indicating complete conversion of the prodrug by plasmin. | Doxorubicin | plasminogen | Homo sapiens |