Title : Sphingosine 1-phosphate induces arachidonic acid mobilization in A549 human lung adenocarcinoma cells.

Pub. Date : 2000 Jan 3

PMID : 10601704






2 Functional Relationships(s)
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1 The Sph-1-P-induced release of arachidonic acid involved Ca(2+)-independent phospholipase A(2) (iPLA2) activity, as suggested by the dose-dependent inhibition exerted by the rather specific inhibitor bromoenol lactone. Arachidonic Acid phospholipase A2 group VI Homo sapiens
2 This study represents the first evidence for Sph-1-P-induced release of arachidonic acid which occurs through a specific signaling pathway involving Gi protein-coupled receptor(s), PKC, PLD and iPLA2 activities. Arachidonic Acid phospholipase A2 group VI Homo sapiens