Title : Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug.

Pub. Date : 1999 Nov

PMID : 10598746






1 Functional Relationships(s)
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1 Microsomes from phenobarbitone and isoniazid-pretreated animals significantly (p < 0.05) enhanced the formation of AQ4 from AQ4N indicating a role for CYP2B and 2E respectively. Phenobarbital cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus