Pub. Date : 1999 Dec
PMID : 10598624
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor. | Tetracaine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | CONCLUSIONS: Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. | Tetracaine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |