Pub. Date : 1999 Nov
PMID : 10595652
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our previous study showed that vanadate, an inhibitor of protein tyrosine phosphatases, induced the expression of cyclo-oxygenase (COX)-2 in a protein-tyrosine-kinase (PTK)-dependent manner in human umbilical vein endothelial cells (HUVEC). | Vanadates | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC. | Vanadates | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Either tyrphostin-47, PD98059, a specific inhibitor of the upstream kinase toward ERK1/2, or SB203580, a specific inhibitor of p38, completely suppressed vanadate-induction of COX-2 mRNA and protein. | Vanadates | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2. | Vanadates | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |