Title : Expression of the mutant thyroid hormone receptor PV in the pituitary of transgenic mice leads to weight reduction.

Pub. Date : 1999 Nov

PMID : 10595466






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The PV mutation is a C-insertion at codon 448 of the TRbeta gene and leads to a frame-shift of the carboxyl-terminal 14 amino acids of TRbeta1, resulting in total loss of triiodothyronine (T3) binding and transcriptional activation. Triiodothyronine thyroid hormone receptor beta Mus musculus
2 The PV mutation is a C-insertion at codon 448 of the TRbeta gene and leads to a frame-shift of the carboxyl-terminal 14 amino acids of TRbeta1, resulting in total loss of triiodothyronine (T3) binding and transcriptional activation. Triiodothyronine thyroid hormone receptor beta Mus musculus