Title : Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.

Pub. Date : 2000 Jan 1

PMID : 10587580






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Machado-Joseph disease (MJD) is an inherited neurodegenerative disorder caused by the expansion of the polyglutamine stretch in the MJD gene-encoded protein, ataxin-3. polyglutamine ataxin 3 Rattus norvegicus
2 These results strongly suggest that the cellular toxicity of truncated ataxin-3 with an expanded polyglutamine stretch is enhanced by cell cycle arrest in the G(0)/G(1)phase. polyglutamine ataxin 3 Rattus norvegicus