Title : Baclofen and midazolam alter c-fos induction by peripheral noxious or innocuous stimulation in the spinal cord of normal and monoarthritic rats.

Pub. Date : 1999 Nov

PMID : 10587093






2 Functional Relationships(s)
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1 caused a significant reduction in the number of Fos-positive neurones following noxious stimulation of both normal and monoarthritic animals, which was prevented by the GABA(B) antagonist CGP 35348 (200 mg/kg, i.v.). gamma-Aminobutyric Acid Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 The paradoxical facilitation of c-fos expression by midazolam in monoarthritic animals, may be due to the reported increase in spinal GABA levels found in those animals. gamma-Aminobutyric Acid Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus