Pub. Date : 1999 Nov
PMID : 10584979
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Omeprazole weakly inhibits CYP1A2 activity in man. | Omeprazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | In this study, a potential inhibitory effect of omeprazole on caffeine metabolism, a validated CYP1A2 marker, was examined. | Omeprazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | In vitro, omeprazole was mainly a competitive CYP1A2 inhibitor with K(i) values of around 150 microM. | Omeprazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 4 | CONCLUSIONS: Omeprazole exerts a concentration-dependent inhibition of CYP1A2 activity in man. | Omeprazole | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |