Title : Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

Pub. Date : 1999 Dec

PMID : 10581028






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. polyglutamine Heat-shock-protein-70Ab Drosophila melanogaster
2 Using a Drosophila melanogaster model of polyglutamine disease, we show that directed expression of the molecular chaperone HSP70 suppresses polyglutamine-induced neurodegeneration in vivo. polyglutamine Heat-shock-protein-70Ab Drosophila melanogaster
3 Using a Drosophila melanogaster model of polyglutamine disease, we show that directed expression of the molecular chaperone HSP70 suppresses polyglutamine-induced neurodegeneration in vivo. polyglutamine Heat-shock-protein-70Ab Drosophila melanogaster
4 Suppression by HSP70 occurred without a visible effect on NI formation, indicating that polyglutamine toxicity can be dissociated from formation of large aggregates. polyglutamine Heat-shock-protein-70Ab Drosophila melanogaster