Title : Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior.

Pub. Date : 1999 Nov 29

PMID : 10579721






1 Functional Relationships(s)
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1 Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Guanine Nucleotides TIAM Rac1 associated GEF 1 Homo sapiens