Title : Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.

Pub. Date : 1999 Nov 15

PMID : 10574795






3 Functional Relationships(s)
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1 The molecular symmetry brings the two bound AMP-PNP molecules, at the centre of two extended surface regions, to a common side of the dimeric hexokinase I molecule. Adenylyl Imidodiphosphate hexokinase 1 Homo sapiens
2 CONCLUSIONS: The binding of AMP-PNP to a protein site separated from the catalytic centre of human hexokinase I can be related to the role played by some nucleotides in dissociating the enzyme from the mitochondrial membrane, and helps in defining the molecular regions of hexokinase I that are expected to be in contact with the mitochondrion. Adenylyl Imidodiphosphate hexokinase 1 Homo sapiens
3 CONCLUSIONS: The binding of AMP-PNP to a protein site separated from the catalytic centre of human hexokinase I can be related to the role played by some nucleotides in dissociating the enzyme from the mitochondrial membrane, and helps in defining the molecular regions of hexokinase I that are expected to be in contact with the mitochondrion. Adenylyl Imidodiphosphate hexokinase 1 Homo sapiens