Pub. Date : 1999 Dec
PMID : 10570064
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Also, preliminary molecular modeling of the interaction between AChE and CPT-11 indicated that the latter does not bind at the same site as tacrine. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | The rapid reversibility of the inhibition of AChE by CPT-11 and the lower activity of the carboxylate form are likely reasons for the transient nature of the cholinergic toxicity observed clinically. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |