Title : The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11).

Pub. Date : 1999 Dec

PMID : 10570064






1 Functional Relationships(s)
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1 The lactone form of CPT-11 resulted in apparent noncompetitive inhibition of electric eel and both human recombinant and erythrocyte AChE with K(i) values of 0.065, 0.19, and 0.29 microM, respectively. Lactones acetylcholinesterase (Cartwright blood group) Homo sapiens