Title : Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.

Pub. Date : 1999 Dec

PMID : 10570018






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. azelastine peptidylprolyl isomerase G Homo sapiens
2 In microsomes from human B-lymphoblast cells, recombinant cytochrome P-450 (CYP)2D6 and CYP1A1 exhibited higher azelastine N-demethylase activity than did other CYP enzymes. azelastine peptidylprolyl isomerase G Homo sapiens