Title : Correlation of oxidant-induced acute ATP depletion with delayed cell death in human neuroblastoma cells.

Pub. Date : 1999 Nov

PMID : 10564080






1 Functional Relationships(s)
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1 Proliferation of both lines decreased, averaging 63 +/- 17% of control by 48 h. Exposure to 5 mM H(2)O(2) caused no further change in ANs in BCL-2 cells but in WT cells decreased the EC to 0.45 +/- 0.08 and depleted ANs to 41 +/- 9% of control; after 24 h, WT cells became pyknotic and showed DNA fragmentation but no chromatin condensation, whereas BCL-2 cells died by delayed necrosis. Hydrogen Peroxide BCL2 apoptosis regulator Homo sapiens