Title : Design of synthetic hexapeptide substrates for prostate-specific antigen using single-position minilibraries.

Pub. Date : 1999 Nov

PMID : 10563510






2 Functional Relationships(s)
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1 Based on these results we have designed and demonstrated the utility of the optimized fluorogenic PSA substrate 7-methoxy-coumarin-4-acetylGlnPheTyrSerSerAsnLys(epsilon-2,4-dinit rophenyl)amide, 1, which permits continuous monitoring of PSA endopeptidase activity at high sensitivity. 7-methoxy-coumarin-4-acetylglnphetyrserserasnlys kallikrein related peptidase 3 Homo sapiens
2 Based on these results we have designed and demonstrated the utility of the optimized fluorogenic PSA substrate 7-methoxy-coumarin-4-acetylGlnPheTyrSerSerAsnLys(epsilon-2,4-dinit rophenyl)amide, 1, which permits continuous monitoring of PSA endopeptidase activity at high sensitivity. 7-methoxy-coumarin-4-acetylglnphetyrserserasnlys kallikrein related peptidase 3 Homo sapiens