Title : CDP-choline: neuroprotection in transient forebrain ischemia of gerbils.

Pub. Date : 1999 Dec 1

PMID : 10561698






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. Phosphatidylcholines cut like homeobox 1 Homo sapiens
2 CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. Phosphatidylcholines cut like homeobox 1 Homo sapiens
3 Exogenous treatment with CDP-choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially arachidonic acid (AA), after ischemia/reperfusion. Phosphatidylcholines cut like homeobox 1 Homo sapiens
4 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Phosphatidylcholines cut like homeobox 1 Homo sapiens
5 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Phosphatidylcholines cut like homeobox 1 Homo sapiens