Title : High-dose, not low-dose insulin increases the vasoconstrictor effect of norepinephrine in spontaneously hypertensive rats: effects of antihypertensive treatment.

Pub. Date : 1999 Sep-Oct

PMID : 10559680






2 Functional Relationships(s)
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1 The increased responsiveness to norepinephrine disappeared after preincubation of the vessels with a selective inhibitor of endothelin-1 type A receptors. Norepinephrine endothelin 1 Rattus norvegicus
2 In conclusion, insulin at high, nonphysiological doses seems to induce an increase in the reactivity to norepinephrine in mesenteric small arteries of SHR, possibly mediated by a local production of endothelin-1. Norepinephrine endothelin 1 Rattus norvegicus