Pub. Date : 1999 Nov 19
PMID : 10559227
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 2 | The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 3 | The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 4 | The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 5 | Here, we have examined if ErbB receptors, other than the EGFR, have a role in regulation of colonic secretion and if differential effects on ErbB receptor activation may explain the ability of the EGFR to propagate diverse signaling pathways in response to EGF versus CCh. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 6 | Further studies revealed that, while both EGF (100 ng/ml) and CCh (100 microM) stimulated phosphorylation of the EGFR, only EGF stimulated phosphorylation of ErbB2, and neither stimulated ErbB3 phosphorylation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 7 | Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 8 | Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh. | Carbachol | epidermal growth factor receptor | Homo sapiens |