Title : Interventions to achieve tonic exposure to levodopa: delaying or preventing the onset of motor complications.

Pub. Date : 1999 Nov

PMID : 10555945






1 Functional Relationships(s)
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1 Entacapone and tolcapone are two potent, selective, and reversible COMT inhibitors that effectively augment levodopa"s pharmacokinetics by increasing area under the plasma concentration versus time curve and plasma elimination half-life without significantly affecting peak levodopa concentrations. entacapone catechol-O-methyltransferase Homo sapiens