Title : Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells.

Pub. Date : 1999 Oct

PMID : 10555165






2 Functional Relationships(s)
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1 mRNA for c-Fos, c-jun and jun-B were up-regulated at 0.5 h after nicotine treatment, elevated c-Fos also being apparent after withdrawal. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 These results indicate that nicotine treatment may affect the transcriptional activity of many genes through c-Fos and c-Jun protein expression in neural cells, and that Fra-1 protein may make a contribution. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens