Title : Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo.

Pub. Date : 1999 Aug

PMID : 10553724






1 Functional Relationships(s)
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1 In a pharmacokinetic study, BP half-life was prolonged to 137% of the average control value by 7-day treatment with erythromycin, a CYP3A inhibitor, and shortened to 58% of the control by 2-day treatment with dexamethasone, a CYP3A inducer. Erythromycin cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus