Title : Metabolism of tauromustine in liver and lung microsomes from various species.

Pub. Date : 1999 Aug

PMID : 10553719






1 Functional Relationships(s)
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1 Both the demethylation and the denitrosation of tauromustine were increased 3-fold in liver microsomes from rat pretreated with phenobarbital, whereas treatment with cyanopregnenolone enhanced the denitrosation 11-fold, indicating the involvement of CYP3A. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens