Pub. Date : 1999 Nov 15
PMID : 10553091
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the TNF-alpha-induced induction of I kappa B kinase (IKK) and IKK beta, without affecting the activation of p38 and c-Jun N-terminal kinase. | sesquiterpene lactone | tumor necrosis factor | Homo sapiens |
| 2 | Therefore, this sesquiterpene lactone could serve as a lead compound for the development of antiinflammatory remedies and is suitable as a molecular tool, allowing the dissection of TNF-alpha-derived signaling pathways leading to the activation of NF-kappa B, c-Jun N-terminal kinase, and p38. | sesquiterpene lactone | tumor necrosis factor | Homo sapiens |